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Initiation of translation on nedicistrovirus and related intergenic region IRESs by their factor-independent binding to the P site of 80S ribosomes

11 Apr 2023

Abstract excerpt

Initiation of translation on many viral mRNAs occurs by noncanonical mechanisms that involve 5′ end-independent binding of ribosomes to an internal ribosome entry site (IRES). The ∼190-nt-long intergenic region (IGR) IRES of dicistroviruses such as cricket paralysis virus (CrPV) initiates translation without Met-tRNAiMetor initiation factors. Advances in metagenomics have revealed numerous dicistrovirus-like...

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PMID: 37041031
DOI: 10.1261/rna.079599.123

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