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Article

TP53-binding protein variants and breast cancer risk: a case-control study.

Breast cancer research : BCR - 1 Jan 2005

Frank Bernd, Hemminki Kari, Bermejo Justo Lorenzo, Klaes Rüdiger, Bugert Peter, Wappenschmidt Barbara, Schmutzler Rita K, Burwinkel Barbara

Abstract excerpt

INTRODUCTION: The TP53-binding protein (53BP1) has been shown to influence TP53-mediated transcriptional activation, thus playing a pivotal role in DNA damage signalling. Genetic aberrations in TP53 and in ATM and CHEK2 predispose to cancer. We have therefore examined the effects of 53BP1 single nucleotide polymorphisms (D353E, G412S, and K1136Q) and the novel 53BP1 6bp deletion (1347_1352delTATCCC) on breast...

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Source

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Identifiers

PMID: 15987456
DOI: 10.1186/bcr1038
PMCID: PMC1175066

Genes

ATM
CHEK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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