Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrative Computational Analysis of TP53 Exon 5-6 Mutations in Oral Cavity, Prostate, and Breast Cancers in a Senegalese Population.

Genes - 20 Feb 2026

Mbaye Mouhamed, Mbaye Fatimata, Sembene Mbacke

Abstract excerpt

Background/Objectives: The tumor suppressor gene TP53 is one of the most frequently mutated genes in human cancers, with alterations predominantly affecting its DNA-binding domain (DBD). However, the mutational landscape and functional consequences of TP53 variants remain poorly characterized in African populations. This study aimed to characterize mutations in exons 5-6 of TP53 in oral cavity cancer (OCC),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Computational Biology
Share to Exons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mouth Neoplasms

Share to Prostatic Neoplasms

Share to Proto-Oncogene Proteins c-bcl-2

Share to Senegal

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 41751629
DOI: 10.3390/genes17020245
PMCID: PMC12940178

Genes

TP53
PC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrative Computational Analysis of TP53 Exon 5-6 Mutations in Oral Cavity, Prostate, and Breast Cancers in a Senegalese Population.PMID 41751629Read ↗

Integrative Computational Analysis of <em>TP53 </em>Exon 5–6 Mutations in Oral Cavity, Prostate, and Breast Cancers in a Senegalese PopulationSemantic proximity Read ↗

Mutational Landscape of TP53 Across Cancer TypesSemantic proximity Read ↗

A Systematic p53 Mutation Library Links Differential Functional Impact to Cancer Mutation Pattern and Evolutionary Conservation.Semantic proximity Read ↗

In Silico Screening, Molecular Dynamics Simulation and Binding Free Energy Identify Single-Point Mutations That Destabilize p53 and Reduce Binding to DNA.Semantic proximity Read ↗

Profiling genetic mutations in the DNA damage repair genes of oral squamous cell carcinoma patients from PakistanSemantic proximity Read ↗

A Systematic p53 Mutation Library Links Differential Functional Impact to Cancer Mutation Pattern and Evolutionary ConservationSemantic proximity Read ↗

Molecular and in-silico analysis of single nucleotide polymorphism targeting human TP53 gene exon 5-8 in Sudanese esophageal cancer patientsSemantic proximity Read ↗

Detailed computational study of p53 and p16: using evolutionary sequence analysis and disease-associated mutations to predict the functional consequences of allelic variantsSemantic proximity Read ↗

Analysis of the genomic landscapes of Barbadian and Nigerian women with triple negative breast cancer.Semantic proximity Read ↗

Analysis of Mutations in Precision Oncology using The Automated, Accurate, and User-Friendly Web Tool PredictONCOSemantic proximity Read ↗

The Mutational Landscape of TP53 in Pakistani Cancer Cohorts: A Systematic Review and Proportion Meta-Analysis for Precision Oncology TargetsSemantic proximity Read ↗

The Mutational Landscape of TP53 in Pakistani Cancer Cohorts: A Systematic Review and Proportion Meta-Analysis for Precision Oncology TargetsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.