Article
Joint effects of single nucleotide polymorphisms in P53BP1 and p53 on breast cancer risk in a Chinese population.
Carcinogenesis - 1 Apr 2006
Ma Hongxia, Hu Zhibin, Zhai Xiangjun, Wang Shui, Wang Xuechen, Qin Jianwei, Chen Wenseng, Jin Guangfu, Liu Jiyong, Gao Jun, Wang Xinru, Wei Qingyi, Shen Hongbing
Abstract excerpt
p53-binding protein 1 (P53BP1), a central transducer of DNA-damage signals to p53, is required for both intra-S-phase and G2-M checkpoints, suggesting that these two proteins may work together in the p53-mediated transcriptional activation and DNA damage-repair signaling pathways. Because the p53-binding region of 53BP1 maps to the C-terminal BRCT domains, which are homologous to those found in the breast cancer...
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