Article
p53 genotypes and haplotypes associated with risk of breast cancer.
Cancer detection and prevention - 1 Jan 2007
Buyru Nur, Altinisik Julide, Demokan Semra, Dalay Nejat
Abstract excerpt
INTRODUCTION: The biological significance of sequence variants in form of SNPs needs to be carefully evaluated, as conflicting associations with cancer predisposition have been reported. Haplotypes, the combination of closely linked alleles on a chromosome, play key roles in the study of the genetic basis of disease. There is strong evidence that different polymorphisms within a single gene in cis position can...
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