Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Germline alterations in the 53BP1 gene in breast and ovarian cancer families.

Cancer letters - 8 Jan 2007

Rapakko Katrin, Heikkinen Katri, Karppinen Sanna-Maria, Erkko Hannele, Winqvist Robert

Abstract excerpt

The conserved TP53-binding protein 1 (53BP1) is a central mediator of the DNA damage checkpoint and appears to be one of the sensors of DNA double-strand breaks (DSBs). Improper processing of DSBs can result in loss or rearrangement of genetic information, leading to cell death or tumorigenesis. 53BP1 interacts with both TP53 and ATM, key proteins involved in the monitoring of genomic integrity and regulation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Gene Frequency
Share to Germ-Line Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Signaling Peptides and Proteins

Share to Ovarian Neoplasms

Share to Phosphoproteins

Share to Polymorphism, Single Nucleotide

Share to Tumor Suppressor p53-Binding Protein 1

Source

Identifiers

PMID: 16517057
DOI: 10.1016/j.canlet.2006.01.021

Genes

ATM
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Germline alterations in the 53BP1 gene in breast and ovarian cancer families.PMID 16517057Read ↗

TP53-binding protein variants and breast cancer risk: a case-control study.Semantic proximity Read ↗

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers.Semantic proximity Read ↗

Identification of a common polymorphism in the TopBP1 gene associated with hereditary susceptibility to breast and ovarian cancer.Semantic proximity Read ↗

TP53 Variations in Human Cancers: New Lessons from the IARC TP53 Database and Genomics Data.Semantic proximity Read ↗

The spectrum of genetic mutations in breast cancer.Semantic proximity Read ↗

Germline mutations of TP53 gene in breast cancer.Semantic proximity Read ↗

Joint effects of single nucleotide polymorphisms in P53BP1 and p53 on breast cancer risk in a Chinese population.Semantic proximity Read ↗

TP53 mutations and SNPs as prognostic and predictive factors in patients with breast cancer (Review)Semantic proximity Read ↗

The role of p53 mutation in BRCA1-associated ovarian cancer.Semantic proximity Read ↗

Genetic polymorphisms of TP53-binding protein 1 (TP53BP1) gene and association with breast cancer risk.Semantic proximity Read ↗

Genome instability in blood cells of a BRCA1+ breast cancer family.Semantic proximity Read ↗

Spectrum of mutations in BRCA1 gene in hereditary forms of breast and ovarian cancer in Russian families.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.