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Article

Polymorphic TP53BP1 and TP53 gene interactions associated with risk of squamous cell carcinoma of the head and neck.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2007

Chen Kexin, Hu Zhibin, Wang Li-E, Zhang Wei, El-Naggar Adel K, Sturgis Erich M, Wei Qingyi

Abstract excerpt

PURPOSE: Tumor protein 53-binding protein 1 (TP53BP1) and TP53 interact during TP53-mediated transcriptional activation and during checkpoint activation in response to DNA damage. Because suboptimal repair of tobacco-induced DNA damage is associated with risk of squamous cell carcinoma of the head and neck (SCCHN), we hypothesized that potentially functional polymorphisms in TP53BP1 and TP53 may contribute...

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Share to Amino Acid Substitution
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Head and Neck Neoplasms

Share to Intracellular Signaling Peptides and Proteins

Share to Mutagenesis, Insertional

Share to Sequence Deletion

Share to Tumor Suppressor p53-Binding Protein 1

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 17634560
DOI: 10.1158/1078-0432.CCR-07-0469

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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