Evaluation of single nucleotide polymorphisms (SNPs) in the p53 binding protein 1 (TP53BP1) gene in breast cancer patients treated with breast-conserving surgery and whole-breast irradiation (BCS + RT).

doi:10.1016/j.ijrobp.2010.02.005

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Article

Evaluation of single nucleotide polymorphisms (SNPs) in the p53 binding protein 1 (TP53BP1) gene in breast cancer patients treated with breast-conserving surgery and whole-breast irradiation (BCS + RT).

International journal of radiation oncology, biology, physics - 1 Jun 2011

Haffty Bruce G, Goyal Sharad, Kulkarni Diptee, Green Camille, Vazquez Alexi, Schiff Devora, Moran Meena S, Yang Qifeng, Ganesan Shridar, Hirsfield Kim M

Abstract excerpt

PURPOSE: TP53BP1 is a key component of radiation-induced deoxyribonucleic acid damage repair. The purpose of this study was to evaluate the significance of a known common single nucleotide polymorphism in this gene (rs560191) in patients treated with breast-conserving surgery and whole-breast irradiation (BCS + RT). METHODS AND MATERIALS: The population consisted of 176 premenopausal women treated with BCS + RT...

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PMID: 20646866
DOI: 10.1016/j.ijrobp.2010.02.005
PMCID: PMC3876421

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