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Article

UGT1A1 polymorphisms are important determinants of dietary carcinogen detoxification in the liver.

Hepatology (Baltimore, Md.) - 1 Aug 2005

Girard Hugo, Thibaudeau Jean, Court Michael H, Fortier Louis-Charles, Villeneuve Lyne, Caron Patrick, Hao Qin, von Moltke Lisa L, Greenblatt David J, Guillemette Chantal

Abstract excerpt

PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-f]pyridine), the most abundant heterocyclic amine in diet, is involved in the etiology of cancer. PhIP and its carcinogenic metabolite N-hydroxy-PhIP (N-OH-PhIP) are extensively conjugated by UDP-glucuronosyltransferase (UGTs) with wide variability. This study aimed to determine the genetic influence of UGTs on the hepatic detoxification of this carcinogen. The formation...

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Identifiers

PMID: 15986396
DOI: 10.1002/hep.20770

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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