Article
CYP1A2 and NAT2 genotype/phenotype relations and urinary excretion of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in a human dietary intervention study.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Jun 2004
Moonen Harald J J, Moonen Edwin J C, Maas Lou, Dallinga Jan W, Kleinjans Jos C S, de Kok Theo M C M
Abstract excerpt
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a mutagenic and carcinogenic heterocyclic amine formed during ordinary cooking, and is subsequently metabolically activated by cytochrome P4501A2 (CYP1A2) and N-acetyltransferase 2 (NAT2). Respective genes encoding for these enzymes, display polymorphic distribution in the human population and are thus believed to cause interindividual differences in...
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