Article
Uridine diphosphoglucuronosyltransferase pharmacogenetics and cancer.
Oncogene - 13 Mar 2006
Nagar S, Remmel R P
Abstract excerpt
The uridine diphosphoglucuronosyltransferases (UGTs) belong to a superfamily of enzymes that catalyse the glucuronidation of numerous endobiotics and xenobiotics. Several human hepatic and extrahepatic UGT isozymes have been characterized with respect to their substrate specificity, tissue expression and gene structure. Genetic polymorphisms have been identified for almost all the UGT family members. A wide...
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