Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic polymorphisms and modulation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-DNA adducts in human lymphocytes.

International journal of cancer - 20 Dec 2003

Magagnotti Cinzia, Pastorelli Roberta, Pozzi Simonetta, Andreoni Bruno, Fanelli Roberto, Airoldi Luisa

Abstract excerpt

2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is the most abundant heterocyclic amine derived from food, possibly involved in human carcinogenesis. We evaluated the formation of PhIP-DNA adducts in lymphocytes from 76 incident colorectal cancer patients likely to be exposed to dietary PhIP. To address the role of the metabolic polymorphisms relevant to PhIP-DNA adduct formation, the patients were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal Neoplasms
Share to Diet

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Adducts

Share to Imidazoles

Share to Lymphocytes

Share to Polymerase Chain Reaction

Share to Polymorphism, Genetic

Share to Polymorphism, Restriction Fragment Length

Source

Identifiers

PMID: 14601045
DOI: 10.1002/ijc.11492

Genes

GSTA1
GSTM1
NAT1
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic polymorphisms and modulation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-DNA adducts in human lymphocytes.PMID 14601045Read ↗

The role of human glutathione S-transferases (hGSTs) in the detoxification of the food-derived carcinogen metabolite N-acetoxy-PhIP, and the effect of a polymorphism in hGSTA1 on colorectal cancer risk.Semantic proximity Read ↗

Genetic polymorphisms in metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine.Semantic proximity Read ↗

UGT1A1 polymorphisms are important determinants of dietary carcinogen detoxification in the liver.Semantic proximity Read ↗

CYP1A2 and NAT2 genotype/phenotype relations and urinary excretion of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in a human dietary intervention study.Semantic proximity Read ↗

High potency of bioactivation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mouse colon epithelial cells with Apc(Min) mutation.Semantic proximity Read ↗

Effect of N-acetyltransferase 2 polymorphism on tumor target tissue DNA adduct levels in rapid and slow acetylator congenic rats administered 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine or 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline.Semantic proximity Read ↗

Heterocyclic aromatic amine [HCA] intake and prostate cancer risk: effect modification by genetic variants.Semantic proximity Read ↗

Metabolic activation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Syrian hamsters congenic at the N-acetyltransferase 2 (NAT2) locus.Semantic proximity Read ↗

Xenobiotic metabolizing gene variants, dietary heterocyclic amine intake, and risk of prostate cancer.Semantic proximity Read ↗

[Heterocyclic aromatic amines, food-derived mutagens: metabolism and relevance to cancer susceptibility].Semantic proximity Read ↗

Red wine consumption is inversely associated with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA adduct levels in prostate.Semantic proximity Read ↗

Cancer chemoprevention from the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazol[4,5-b]pyridine: reconsideration of the evidence.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.