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Article

Selective blockade of BAFF for the prevention and treatment of systemic lupus erythematosus nephritis in NZM2410 mice.

Arthritis and rheumatism - 1 May 2010

Ramanujam Meera, Bethunaickan Ramalingam, Huang Weiqing, Tao Haiou, Madaio Michael P, Davidson Anne

Abstract excerpt

OBJECTIVE: To determine whether BAFF or combined BAFF/APRIL blockade is effective in a mouse model of systemic lupus erythematosus (SLE) nephritis characterized by rapidly progressive glomerulosclerosis. METHODS: NZM2410 mice at early and late stages of SLE nephritis were treated with a short course of BAFF-R-Ig or TACI-Ig fusion protein. Proteinuria and serologic profile were evaluated every 2 weeks....

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Identifiers

PMID: 20131293
DOI: 10.1002/art.27368
PMCID: PMC2917190

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Source receipt: pubmed, retrieved 7 Sept 2026.

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