Article
CYP1A1 gene polymorphisms increase lung cancer risk in a high-incidence region of Spain: a case control study.
BMC cancer - 30 Aug 2010
San Jose Carmen, Cabanillas Agustin, Benitez Julio, Carrillo Juan Antonio, Jimenez Mercedes, Gervasini Guillermo
Abstract excerpt
BACKGROUND: A rural region in south-west Spain has one of the highest lung cancer incidence rates of the country, as revealed by a previous epidemiological 10-year follow-up study. The present work was undertaken to ascertain the role of CYP1A1 gene polymorphisms and their interaction with tobacco smoking in the development of the disease in this location. METHODS: One-hundred-and-three cases of lung cancer and...
Topics
- Adenocarcinoma
- Aged
- Carcinoma, Large Cell
- Carcinoma, Squamous Cell
- Case-Control Studies
- Cytochrome P-450 CYP1A1
- DNA
- Female
- Genetic Predisposition to Disease
- Genotype
- Humans
- Incidence
- Lung Neoplasms
- Male