Article
Metabolic gene polymorphisms and lung cancer risk in non-smokers. An update of the GSEC study.
Mutation research - 30 Dec 2005
Raimondi Sara, Boffetta Paolo, Anttila Sisko, Bröckmoller Jürgen, Butkiewicz Dorota, Cascorbi Ingolf, Clapper Margie L, Dragani Tommaso A, Garte Seymour, Gsur Andre, Haidinger Gerald, Hirvonen Ari, Ingelman-Sundberg Magnus, Kalina Ivan, Lan Qing, Leoni Vera Piera, Le Marchand Loïc, London Stephanie J, Neri Monica, Povey Andrew C, Rannug Agneta, Reszka Edyta, Ryberg David, Risch Angela, Romkes Marjorie, Ruano-Ravina Alberto, Schoket Bernadette, Spinola Monica, Sugimura Haruhiko, Wu Xifeng, Taioli Emanuela
Abstract excerpt
BACKGROUND: Since genetic factors may play an important role in lung cancer development at low dose carcinogen exposure, non-smokers are a good model to study genetic susceptibility and its interaction with environmental factors. MATERIALS AND METHODS: We evaluated the role of the metabolic gene polymorphisms CYP1A1MspI, CYP1A1Ile462Val, GSTM1, and GSTT1 in non-smoker lung cancer patients from the International...
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