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Article

Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage.

The Journal of experimental medicine - 4 Jul 2005

Porse Bo T, Bryder David, Theilgaard-Mönch Kim, Hasemann Marie S, Anderson Kristina, Damgaard Inge, Jacobsen Sten Eirik W, Nerlov Claus

Abstract excerpt

CCAAT/enhancer binding protein (C/EBP)alpha is a myeloid-specific transcription factor that couples lineage commitment to terminal differentiation and cell cycle arrest, and is found mutated in 9% of patients who have acute myeloid leukemia (AML). We previously showed that mutations which dissociate the ability of C/EBP alpha to block cell cycle progression through E2F inhibition from its function as a...

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Source

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Identifiers

PMID: 15983063
DOI: 10.1084/jem.20050067
PMCID: PMC2212897

Genes

EBP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage.PMID 15983063Read ↗

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