Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein α-deficient mice

21 Jan 1997

Abstract excerpt

Transcription factors are master regulatory switches of differentiation, including the development of specific hematopoietic lineages from stem cells. Here we show that mice with targeted disruption of the CCAAT enhancer binding protein alpha gene (C/EBP alpha) demonstrate a selective block in differentiation of neutrophils. Mature neutrophils and eosinophils are not observed in the blood or fetal liver of mutant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Hematopoietic Stem Cell Transplantation
Share to Immune cells in cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9012825
DOI: 10.1073/pnas.94.2.569

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein α-deficient micePMID 9012825Read ↗

Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage.Semantic proximity Read ↗

Multipotent hematopoietic cell lines derived from C/EBPalpha(-/-) knockout mice display granulocyte macrophage-colony-stimulating factor, granulocyte- colony-stimulating factor, and retinoic acid-induced granulocytic differentiation.Semantic proximity Read ↗

Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein ɛ-deficient miceSemantic proximity Read ↗

Induction of granulocytic differentiation by 2 pathwaysSemantic proximity Read ↗

Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta.Semantic proximity Read ↗

Development of hematopoietic cells lacking transcription factor GATA-1Semantic proximity Read ↗

Neutrophil-specific granule deficiency results from a novel mutation with loss of function of the transcription factor CCAAT/enhancer binding protein epsilon.Semantic proximity Read ↗

The amino terminal and E2F interaction domains are critical for C/EBP alpha-mediated induction of granulopoietic development of hematopoietic cells.Semantic proximity Read ↗

Neutrophil specific granule deficiency and mutations in the gene encoding transcription factor C/EBP(epsilon).Semantic proximity Read ↗

Stroma-mediated dysregulation of myelopoiesis in mice lacking I kappa B alpha.Semantic proximity Read ↗

Cebpα is essential for the embryonic myeloid progenitor and neutrophil maintenance in zebrafish.Semantic proximity Read ↗

The Role of C/EBPε in the Terminal Stages of Granulocyte DifferentiationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.