Article
Mouse and human resistins impair glucose transport in primary mouse cardiomyocytes, and oligomerization is required for this biological action.
The Journal of biological chemistry - 9 Sept 2005
Graveleau Christophe, Zaha Vlad G, Mohajer Arash, Banerjee Ronadip R, Dudley-Rucker Nicole, Steppan Claire M, Rajala Michael W, Scherer Philipp E, Ahima Rexford S, Lazar Mitchell A, Abel E Dale
Abstract excerpt
The adipocytokine resistin impairs glucose tolerance and insulin sensitivity in rodents. Here, we examined the effect of resistin on glucose uptake in isolated adult mouse cardiomyocytes. Murine resistin reduced insulin-stimulated glucose uptake, establishing the heart as a resistin target tissue. Notably, human resistin also impaired insulin action in mouse cardiomyocytes, providing the first evidence that human...
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