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Article

Disulfide-dependent multimeric assembly of resistin family hormones.

Science (New York, N.Y.) - 21 May 2004

Patel Saurabh D, Rajala Michael W, Rossetti Luciano, Scherer Philipp E, Shapiro Lawrence

Abstract excerpt

Resistin, founding member of the resistin-like molecule (RELM) hormone family, is secreted selectively from adipocytes and induces liver-specific antagonism of insulin action, thus providing a potential molecular link between obesity and diabetes. Crystal structures of resistin and RELMbeta reveal an unusual multimeric structure. Each protomer comprises a carboxy-terminal disulfide-rich beta-sandwich "head"...

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Identifiers

PMID: 15155948
DOI: 10.1126/science.1093466

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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