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Article

Transgenic and recombinant resistin impair skeletal muscle glucose metabolism in the spontaneously hypertensive rat.

The Journal of biological chemistry - 14 Nov 2003

Pravenec Michal, Kazdová Ludmila, Landa Vladimir, Zidek Václav, Mlejnek Petr, Jansa Petr, Wang Jiaming, Qi Nianning, Kurtz Theodore W

Abstract excerpt

Increased serum levels of resistin, a molecule secreted by fat cells, have been proposed as a possible mechanistic link between obesity and insulin resistance. To further investigate the effects of resistin on glucose metabolism, we derived a novel transgenic strain of spontaneously hypertensive rats expressing the mouse resistin gene under the control of the fat-specific aP2 promoter and also performed in vitro...

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Identifiers

PMID: 12944409
DOI: 10.1074/jbc.M304869200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Transgenic and recombinant resistin impair skeletal muscle glucose metabolism in the spontaneously hypertensive rat.PMID 12944409Read ↗

A promoter genotype and oxidative stress potentially link resistin to human insulin resistance.Semantic proximity Read ↗

Mouse and human resistins impair glucose transport in primary mouse cardiomyocytes, and oligomerization is required for this biological action.Semantic proximity Read ↗

Human Resistin Gene: Molecular Scanning and Evaluation of Association with Insulin Sensitivity and Type 2 Diabetes in CaucasiansSemantic proximity Read ↗

Adipocytokines and the regulation of lipid metabolism in growth hormone transgenic and calorie-restricted mice.Semantic proximity Read ↗

Variation in the resistin gene is associated with obesity and insulin-related phenotypes in Finnish subjects.Semantic proximity Read ↗

Absence of evidence for an association between resistin gene variants and insulin resistance in an Asian population with low and high blood pressure.Semantic proximity Read ↗

Skeletal muscle of stroke-prone spontaneously hypertensive rats exhibits reduced insulin-stimulated glucose transport and elevated levels of caveolin and flotillin.Semantic proximity Read ↗

A potential role for insulin resistance in experimental pulmonary hypertension.Semantic proximity Read ↗

Insulin resistance and type 2 diabetes are not related to resistin expression in human fat cells or skeletal muscle.Semantic proximity Read ↗

Alterations in Adiposity and Glucose Homeostasis in Adult Gasp-1 Overexpressing Mice.Semantic proximity Read ↗

Resistin Gene Expression in Human Adipocytes Is Not Related to Insulin ResistanceSemantic proximity Read ↗

Human Resistin Gene, Obesity, and Type 2 DiabetesSemantic proximity Read ↗

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