Article
Transgenic and recombinant resistin impair skeletal muscle glucose metabolism in the spontaneously hypertensive rat.
The Journal of biological chemistry - 14 Nov 2003
Pravenec Michal, Kazdová Ludmila, Landa Vladimir, Zidek Václav, Mlejnek Petr, Jansa Petr, Wang Jiaming, Qi Nianning, Kurtz Theodore W
Abstract excerpt
Increased serum levels of resistin, a molecule secreted by fat cells, have been proposed as a possible mechanistic link between obesity and insulin resistance. To further investigate the effects of resistin on glucose metabolism, we derived a novel transgenic strain of spontaneously hypertensive rats expressing the mouse resistin gene under the control of the fat-specific aP2 promoter and also performed in vitro...
Topics
- Adipocytes
- Animals
- Animals, Genetically Modified
- Blotting, Northern
- Blotting, Western
- Body Weight
- Glucose
- Glucose Tolerance Test
- Glycogen
- Hormones, Ectopic