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Article

BMPR2 dysfunction impairs insulin signaling and glucose homeostasis in cardiomyocytes.

American journal of physiology. Lung cellular and molecular physiology - 1 Feb 2020

Hemnes Anna R, Fessel Joshua P, Chen Xinping, Zhu Shijun, Fortune Niki L, Jetter Christopher, Freeman Michael, Newman John H, West James D, Talati Megha H

Abstract excerpt

Insulin resistance and right ventricular (RV) dysfunction are associated with lipotoxicity in heritable forms of pulmonary arterial hypertension (PAH), commonly due to mutations in bone morphogenetic protein receptor type 2 (BMPR2). How BMPR2 dysfunction in cardiomyocytes alters glucose metabolism and the response of these cells to insulin are unknown. We hypothesized that BMPR2 mutation in cardiomyocytes alters...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31850803
DOI: 10.1152/ajplung.00555.2018
PMCID: PMC7052666

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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