Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variation including nonsynonymous polymorphisms of a major aggrecanase, ADAMTS-5, in susceptibility to osteoarthritis.

Arthritis and rheumatism - 1 Feb 2008

Rodriguez-Lopez Julio, Mustafa Zehra, Pombo-Suarez Manuel, Malizos Konstantinos N, Rego Ignacio, Blanco Francisco J, Tsezou Aspasia, Loughlin John, Gomez-Reino Juan J, Gonzalez Antonio

Abstract excerpt

OBJECTIVE: Given the recent characterization of ADAMTS-5 as the main aggrecanase of cartilage destruction in mouse models, we explored whether genetic variation and, in particular, putative damaging polymorphisms in the ADAMTS-5 gene modify susceptibility to osteoarthritis (OA). METHODS: Two likely deleterious nonsynonymous single-nucleotide polymorphisms (SNPs) were identified in ADAMTS-5 by bioinformatics...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADAM Proteins
Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genetic Variation

Share to Haplotypes

Share to Linkage Disequilibrium

Share to Osteoarthritis

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 18240210
DOI: 10.1002/art.23201

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variation including nonsynonymous polymorphisms of a major aggrecanase, ADAMTS-5, in susceptibility to osteoarthritis.PMID 18240210Read ↗

Association of ADAMTS-5 gene polymorphisms with the susceptibility to knee osteoarthritis in a Chinese Han population.Semantic proximity Read ↗

Association of ADAMTS-5 gene polymorphisms with the susceptibility to knee osteoarthritis in a Chinese Han populationSemantic proximity Read ↗

Polymorphisms in ADAMTS4 and ADAMTS5 are not linked to susceptibility to knee osteoarthritis in the Turkish population.Semantic proximity Read ↗

Elucidation of the Mechanism by Which a ADAMTS5 Gene MicroRNA-Binding Site Single Nucleotide Polymorphism Affects the Risk of Osteoarthritis.Semantic proximity Read ↗

The Decisive Case-Control Study Elaborates the Null Association between ADAMTS5 rs226794 and Osteoarthritis in Asians: A Case-Control Study and Meta-Analysis.Semantic proximity Read ↗

Association of a nsSNP in ADAMTS14 to some osteoarthritis phenotypes.Semantic proximity Read ↗

Haplotypes of the low-density lipoprotein receptor-related protein 5 (LRP5) gene: are they a risk factor in osteoarthritis?Semantic proximity Read ↗

Analysis of single nucleotide polymorphisms within ADAM12 and risk of knee osteoarthritis in a Chinese Han population.Semantic proximity Read ↗

Genetic epidemiology of hip and knee osteoarthritis.Semantic proximity Read ↗

Identification of novel genetic variations affecting osteoarthritis patients.Semantic proximity Read ↗

Association of single nucleotide polymorphisms in ADAM12 gene with susceptibility to knee osteoarthritis: a case-control study in a Chinese Han population.Semantic proximity Read ↗

The association between ADAM12 gene polymorphisms and osteoarthritis: an updated meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.