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Article

Evaluation of the association between a single-nucleotide polymorphism of bone morphogenetic proteins 5 gene and risk of knee osteoarthritis.

Journal of postgraduate medicine - 1 Jan 2000

Sharma A C, Srivastava R N, Srivastava S R, Agrahari A, Singh A, Parmar D

Abstract excerpt

BACKGROUND: Osteoarthritis (OA) is a chronic degenerative disorder probably affected by both genetic and environmental causes. Bone morphogenetic proteins (BMPs) are bone-derived factors that can induce new bone formation. Single-nucleotide polymorphisms (SNPs) of BMP5 gene alters the transcriptional activity of the BMP5 promoter that has been involved in OA susceptibility. This case-control study investigated...

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Identifiers

PMID: 28695869
DOI: 10.4103/jpgm.JPGM_450_16
PMCID: PMC5525478

Genes

BMP5

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