Article
The MC4 receptor and control of appetite.
British journal of pharmacology - 1 Dec 2006
Adan R A H, Tiesjema B, Hillebrand J J G, la Fleur S E, Kas M J H, de Krom M
Abstract excerpt
Mutations in the human melanocortin (MC)4 receptor have been associated with obesity, which underscores the relevance of this receptor as a drug target to treat obesity. Infusion of MC4R agonists decreases food intake, whereas inhibition of MC receptor activity by infusion of an MC receptor antagonist or with the inverse agonist AgRP results in increased food intake. This review addresses the role of the MC...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.