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Alcohol drinking in MCH receptor-1-deficient mice.

Alcoholism, clinical and experimental research - 1 Aug 2007

Duncan Elizabeth A, Sorrell Joyce E, Adamantidis Antoine, Rider Therese, Jandacek Ronald J, Seeley Randy J, Lakaye Bernard, Woods Stephen C

Abstract excerpt

BACKGROUND: Recently, we demonstrated that exogenous melanin-concentrating hormone (MCH) increases alcohol drinking in rats when administered into the brain. However, because the physiological relevance of this finding is unclear, we tested the hypothesis that endogenous MCH signaling enhances alcohol consumption. METHODS: Alcohol intake was assessed in male and female wildtype (WT), heterozygous (HET), and...

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Identifiers

PMID: 17550369
DOI: 10.1111/j.1530-0277.2007.00427.x

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