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Article

Retrodifferentiation and rejuvenation of senescent monocytic cells requires PARP-1.

Experimental gerontology - 1 Jun 2007

Selle Astrid, Ullrich Oliver, Harnacke Katja, Hass Ralf

Abstract excerpt

Long-term culture of phorbol ester (TPA)-differentiated and growth-arrested human U937 leukemia cells was associated with expression of c-jun transcription factors and vimentin intermediate filaments until the cells entered a retrodifferentiation program. This retrodifferentiation process revealed a reversion of the senecent differentiated cells back to undifferentiated and proliferative active young cells. A...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 17314023
DOI: 10.1016/j.exger.2006.12.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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