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Article

Proteomic analysis of acute promyelocytic leukemia: PML-RARalpha leads to decreased phosphorylation of OP18 at serine 63.

Proteomics - 1 Nov 2006

Zada Abdul A Peer, Geletu Mulu H, Pulikkan John A, Müller-Tidow Carsten, Reddy Venkateshwar A, Christopeit Maximilian, Hiddemann Wolfgang D, Behre Hermann M, Tenen Daniel G, Behre Gerhard

Abstract excerpt

In the present study, we employed 2-DE to characterize the effect of the acute promyelocytic leukemia (APL)-specific PML-RARalpha fusion protein on the proteome. Differentially expressed proteins, a number of which are related to the cell cycle function, including oncoprotein18 (OP18), heat shock protein70, glucose-regulated protein75, and peptidyl-prolyl isomerase, were identified by MS. Subsequent bioinformatic...

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Share to Electrophoresis, Gel, Two-Dimensional
Share to Leukemia, Promyelocytic, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Oncogene Proteins, Fusion

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Source

Identifiers

PMID: 17001604
DOI: 10.1002/pmic.200600307

Genes

PML
MYC
SMARCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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