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Article

Gelsolin induces promonocytic leukemia differentiation accompanied by upregulation of p21CIP1.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2012

Shirkoohi Reza, Fujita Hisakazu, Darmanin Stephanie, Takimoto Masato

Abstract excerpt

Tumor suppressor genes have received much attention for their roles in the development of human malignancies. Gelsolin has been found to be down-regulated in several types of human cancers, including leukemias. It is, however, expressed in macrophages, which are the final differentiation derivatives for the monocytic myeloid lineage, implicating this protein in the differentiation process of such cells. In order...

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PMID: 23167427
DOI: 10.7314/apjcp.2012.13.9.4827

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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