Article
Regulation of cell death protease caspase-9 by phosphorylation.
Science (New York, N.Y.) - 13 Nov 1998
Cardone M H, Roy N, Stennicke H R, Salvesen G S, Franke T F, Stanbridge E, Frisch S, Reed J C
Abstract excerpt
Caspases are intracellular proteases that function as initiators and effectors of apoptosis. The kinase Akt and p21-Ras, an Akt activator, induced phosphorylation of pro-caspase-9 (pro-Casp9) in cells. Cytochrome c-induced proteolytic processing of pro-Casp9 was defective in cytosolic extracts fr...
Topics
- Apoptosis
- Caspase 9
- Caspase Inhibitors
- Caspases
- Cell Line
- Cytochrome c Group
- Enzyme Precursors
- Humans
- Mass Spectrometry
- Mutation
- Peptide Fragments
- Phosphorylation
- Phosphoserine
- Protein Serine-Threonine Kinases
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-akt
- Proto-Oncogene Proteins p21(ras)
- Recombinant Fusion Proteins