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Article

Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation.

The EMBO journal - 1 Mar 1999

Asada M, Yamada T, Ichijo H, Delia D, Miyazono K, Fukumuro K, Mizutani S

Abstract excerpt

p21(Cip1/WAF1) inhibits cell-cycle progression by binding to G1 cyclin/CDK complexes and proliferating cell nuclear antigen (PCNA) through its N- and C-terminal domains, respectively. The cell-cycle inhibitory activity of p21(Cip1/WAF1) is correlated with its nuclear localization. Here, we report a novel cytoplasmic localization of p21(Cip1/WAF1) in peripheral blood monocytes (PBMs) and in U937 cells undergoing...

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Identifiers

PMID: 10064589
DOI: 10.1093/emboj/18.5.1223
PMCID: PMC1171213

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Related research

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Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation.PMID 10064589Read ↗

Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase.Semantic proximity Read ↗

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.Semantic proximity Read ↗

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Identification of the region required for the antiapoptotic function of the cyclin kinase inhibitor, p21.Semantic proximity Read ↗

STIM2 is involved in the regulation of apoptosis and cell cycle in normal and malignant monocytic cellsSemantic proximity Read ↗

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