Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human Proteinase-3 Expression Is Regulated by PU.1 in Conjunction with a Cytidine-rich Element

1 Dec 1996

Abstract excerpt

Human proteinase-3 is one of three serine proteinases present in the azurophil granules of polymorphonuclear leukocytes along with elastase and cathepsin G. Proteinase-3 gene expression is confined to the promyelocytic stage of polymorphonuclear leukocyte maturation. The present investigation identifies elements responsible for this highly controlled tissue- and developmental-specific expression of proteinase-3....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Coagulation and Thrombosis Mechanisms
Share to Cell Adhesion Molecules Research
Share to Protease and Inhibitor Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8943304
DOI: 10.1074/jbc.271.50.32392

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human Proteinase-3 Expression Is Regulated by PU.1 in Conjunction with a Cytidine-rich ElementPMID 8943304Read ↗

Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter.Semantic proximity Read ↗

The proximal promoter of the human cathepsin G gene conferring myeloid-specific expression includes C/EBP, c-myb and PU.1 binding sites.Semantic proximity Read ↗

The - 564 A/G polymorphism in the promoter region of the proteinase 3 gene associated with Wegener's granulomatosis does not increase the promoter activity.Semantic proximity Read ↗

PU.1 regulates the expression of the human neutrophil elastase gene.Semantic proximity Read ↗

Identification of novel functional sequence variants in the gene for peptidase inhibitor 3.Semantic proximity Read ↗

The Human Proteinase-activated Receptor-3 (PAR-3) GeneSemantic proximity Read ↗

Dysregulation of Autoantigen Genes in ANCA-Associated Vasculitis Involves Alternative Transcripts and New Protein SynthesisSemantic proximity Read ↗

Membrane expression of proteinase 3 is genetically determined.Semantic proximity Read ↗

Increased neutrophil membrane expression and plasma level of proteinase 3 in systemic vasculitis are not a consequence of the - 564 A/G promotor polymorphism.Semantic proximity Read ↗

Cleavage of p21/WAF1/CIP1 by proteinase 3 modulates differentiation of a monocytic cell line. Molecular analysis of the cleavage site.Semantic proximity Read ↗

Bimodal distribution of proteinase 3 (PR3) surface expression reflects a constitutive heterogeneity in the polymorphonuclear neutrophil pool.Semantic proximity Read ↗

Negative and positive cis-acting elements control the expression of murine alpha 1-protease inhibitor genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.