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Article

Safrole Induces Apoptosis in Human Oral Cancer HSC-3 Cells

20 Dec 2010

Abstract excerpt

Phytochemicals have been used as potential chemopreventive or chemotherapeutic agents. However, there are data suggesting a mutagenic effect of some phytochemicals. We hypothesized that safrole would have anticancer effects on human oral squamous cell carcinoma HSC-3 cells. Safrole decreased the percentage of viable HSC-3 cells via induction of apoptosis by an increased level of cytosolic Ca(2+) and a reduction...

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PMID: 21173435
DOI: 10.1177/0022034510384619

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