Article
Depression of p53-independent Akt survival signals in human oral cancer cells bearing mutated p53 gene after exposure to high-LET radiation.
Biochemical and biophysical research communications - 13 Jul 2012
Nakagawa Yosuke, Takahashi Akihisa, Kajihara Atsuhisa, Yamakawa Nobuhiro, Imai Yuichiro, Ota Ichiro, Okamoto Noritomo, Mori Eiichiro, Noda Taichi, Furusawa Yoshiya, Kirita Tadaaki, Ohnishi Takeo
Abstract excerpt
Although mutations and deletions in the p53 tumor suppressor gene lead to resistance to low linear energy transfer (LET) radiation, high-LET radiation efficiently induces cell lethality and apoptosis regardless of the p53 gene status in cancer cells. Recently, it has been suggested that the induction of p53-independent apoptosis takes place through the activation of Caspase-9 which results in the cleavage of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.