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Article

High LET radiation enhances apoptosis in mutated p53 cancer cells through Caspase-9 activation.

Cancer science - 1 Jul 2008

Yamakawa Nobuhiro, Takahashi Akihisa, Mori Eiichiro, Imai Yuichiro, Furusawa Yoshiya, Ohnishi Ken, Kirita Tadaaki, Ohnishi Takeo

Abstract excerpt

Although mutations in the p53 gene can lead to resistance to radiotherapy, chemotherapy and thermotherapy, high linear energy transfer (LET) radiation induces apoptosis regardless of p53 gene status in cancer cells. The aim of this study was to clarify the mechanisms involved in high LET radiation-induced apoptosis. Human gingival cancer cells (Ca9-22 cells) containing a mutated p53 (mp53) gene were irradiated...

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Source

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Identifiers

PMID: 18422753
DOI: 10.1111/j.1349-7006.2008.00818.x
PMCID: PMC11158808

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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