Article
High linear energy transfer carbon radiation effectively kills cultured glioma cells with either mutant or wild-type p53.
International journal of radiation oncology, biology, physics - 1 Jul 2001
Iwadate Y, Mizoe J, Osaka Y, Yamaura A, Tsujii H
Abstract excerpt
PURPOSE: A mutation in the p53 gene is believed to play an important role in the radioresistance of many cancer cell lines. We studied cytotoxic effects of high linear energy transfer (LET) carbon beams on glioma cell lines with either mutant or wild-type p53. METHODS AND MATERIALS: Cell lines U-87 and U-138 expressing wild-type p53 and U-251 and U-373 expressing mutant p53 were used. These cells were irradiated...
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