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Article

Mechanoregulation of intracellular Ca2+ concentration is attenuated in collecting duct of monocilium-impaired orpk mice.

American journal of physiology. Renal physiology - 1 Nov 2005

Liu Wen, Murcia Noel S, Duan Yi, Weinbaum Sheldon, Yoder Bradley K, Schwiebert Erik, Satlin Lisa M

Abstract excerpt

Autosomal recessive polycystic kidney disease (ARPKD) is characterized by the progressive dilatation of collecting ducts, the nephron segments responsible for the final renal regulation of sodium, potassium, acid-base, and water balance. Murine models of ARPKD possess mutations in genes encoding cilia-associated proteins, including Tg737 in orpk mice. New findings implicate defects in structure/function of...

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Identifiers

PMID: 15972389
DOI: 10.1152/ajprenal.00260.2004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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