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Article

The oscillation of intracellular Ca2+ influx associated with the circadian expression of Piezo1 and TRPV4 in the bladder urothelium.

Scientific reports - 9 Apr 2018

Ihara Tatsuya, Mitsui Takahiko, Nakamura Yuki, Kanda Mie, Tsuchiya Sachiko, Kira Satoru, Nakagomi Hiroshi, Sawada Norifumi, Kamiyama Manabu, Hirayama Yuri, Shigetomi Eiji, Shinozaki Youichi, Yoshiyama Mitsuharu, Nakao Atsuhito, Takeda Masayuki, Koizumi Schuichi

Abstract excerpt

We previously showed that bladder functions are controlled by clock genes with circadian rhythm. The sensation of bladder fullness (SBF) is sensed by mechano-sensor such as Piezo1 and TRPV4 in the mouse bladder urothelium. However, functional circadian rhythms of such mechano-sensors remain unknown. To investigate functional circadian changes of these mechano-sensors, we measured circadian changes in...

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Identifiers

PMID: 29632308
DOI: 10.1038/s41598-018-23115-w
PMCID: PMC5890282

Genes

TRPV4

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