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A substitution in the glutathione reductase lowers electron leakage and inflammation in modern humans

5 Jan 2022

Abstract excerpt

Glutathione reductase is a critical enzyme for preventing oxidative stress and maintaining a reduced intracellular environment. Almost all present-day humans carry an amino acid substitution (S232G) in this enzyme relative to apes and Neanderthals. We express the modern human and the ancestral enzymes and show that whereas the activity and stability are unaffected by the amino acid substitution, the ancestral...

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PMID: 34985944
DOI: 10.1126/sciadv.abm1148

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