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Article

PTEN loss inhibits CHK1 to cause double stranded-DNA breaks in cells.

Cell cycle (Georgetown, Tex.) - 1 Jul 2005

Puc Janusz, Parsons Ramon

Abstract excerpt

CHK1 is an essential kinase involved in the regulation of the cell cycle progression and preservation of genomic integrity. Inhibition of CHK1 leads to the accumulation of double-stranded DNA breaks. Loss of PTEN impairs CHK1-mediated checkpoint activation due to cytoplasmic sequestration of ubiquitinated CHK1. Here, we provide evidence that another consequence of reduced CHK1 function in PTEN deficient cells is...

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Identifiers

PMID: 15970699
DOI: 10.4161/cc.4.7.1795

Genes

PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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