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Article

Lack of PTEN sequesters CHK1 and initiates genetic instability.

Cancer cell - 1 Feb 2005

Puc Janusz, Keniry Megan, Li Hong Shen, Pandita Tej K, Choudhury Atish D, Memeo Lorenzo, Mansukhani Mahesh, Murty Vundavalli V V S, Gaciong Zbigniew, Meek Sarah E M, Piwnica-Worms Helen, Hibshoosh Hanina, Parsons Ramon

Abstract excerpt

Pten-/- cells display a partially defective checkpoint in response to ionizing radiation (IR). The checkpoint defect was traced to the ability of AKT to phosphorylate CHK1 at serine 280, since a nonphosphorylated mutant of CHK1 (S280A) complemented the checkpoint defect and restored CDC25A degradation. CHK1 phosphorylation at serine 280 led to covalent binding of 1 to 2 molecules of ubiquitin and cytoplasmic CHK1...

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Share to Checkpoint Kinase 1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15710331
DOI: 10.1016/j.ccr.2005.01.009

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Lack of PTEN sequesters CHK1 and initiates genetic instability.PMID 15710331Read ↗

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Loss of PTEN-assisted G2/M checkpoint impedes homologous recombination repair and enhances radio-curability and PARP inhibitor treatment response in prostate cancerSemantic proximity Read ↗

Chk1 is haploinsufficient for multiple functions critical to tumor suppression.Semantic proximity Read ↗

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