Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Brca1 and differentiation.

Mutation research - 1 Dec 2002

Kubista Marion, Rosner Margit, Miloloza Angelina, Hofer Katja, Prusa Andrea-Romana, Kroiss Regina, Marton Erika, Hengstschläger Markus

Abstract excerpt

Breast cancer is one of the most frequent malignancies affecting women. The human breast cancer gene 1 (BRCA1) gene is mutated in a distinct proportion of hereditary breast and ovarian cancers. Tumourigenesis in individuals with germline BRCA1 mutations requires somatic inactivation of the remaining wild-type allelle. Although, this evidence supports a role for BRCA1 as a tumour suppressor, the mechanisms through...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Cell Differentiation
Share to Cell Division

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Genes, BRCA1

Share to Ovarian Neoplasms

Share to Receptors, Estrogen

Share to Signal Transduction

Source

Identifiers

PMID: 12464350
DOI: 10.1016/s1383-5742(02)00063-7

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Brca1 and differentiation.PMID 12464350Read ↗

Brca1 regulates in vitro differentiation of mammary epithelial cells.Semantic proximity Read ↗

Emerging roles of BRCA1 in transcriptional regulation and DNA repair.Semantic proximity Read ↗

Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells.Semantic proximity Read ↗

BRACking news on triple-negative/basal-like breast cancers: how BRCA1 deficiency may result in the development of a selective tumor subtype.Semantic proximity Read ↗

The functions of breast cancer susceptibility gene 1 (BRCA1) product and its associated proteins.Semantic proximity Read ↗

Understanding the functions of BRCA1 in the DNA-damage response.Semantic proximity Read ↗

Enhanced cancer cell proliferation and aggressive phenotype counterbalance in breast cancer with high BRCA1 gene expression.Semantic proximity Read ↗

BRCA1/2 mutations perturb telomere biology: characterization of structural and functional abnormalities in vitro and in vivo.Semantic proximity Read ↗

BRCA1 in breast and ovarian cancer predisposition.Semantic proximity Read ↗

Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate.Semantic proximity Read ↗

BRCA1 and prostate cancer.Semantic proximity Read ↗

BRCA1: the enigma of tissue-specific tumor development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.