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Article

BRCA1/FANCD2/BRG1-Driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells.

Molecular cell - 21 Jul 2016

Wang Hua, Bierie Brian, Li Andrew G, Pathania Shailja, Toomire Kimberly, Dimitrov Stoil D, Liu Ben, Gelman Rebecca, Giobbie-Hurder Anita, Feunteun Jean, Polyak Kornelia, Livingston David M

Abstract excerpt

An abnormal differentiation state is common in BRCA1-deficient mammary epithelial cells, but the underlying mechanism is unclear. Here, we report a convergence between DNA repair and normal, cultured human mammary epithelial (HME) cell differentiation. Surprisingly, depleting BRCA1 or FANCD2 (Fanconi anemia [FA] proteins) or BRG1, a mSWI/SNF subunit, caused HME cells to undergo spontaneous...

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Identifiers

PMID: 27373334
DOI: 10.1016/j.molcel.2016.05.038
PMCID: PMC4982517

Genes

BRCA1
FANCD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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