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Article

Rapid turnover of GATA-2 via ubiquitin-proteasome protein degradation pathway.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Jul 2005

Minegishi Naoko, Suzuki Norio, Kawatani Yukie, Shimizu Ritsuko, Yamamoto Masayuki

Abstract excerpt

Transcription factor GATA-2 is expressed in a number of tissues, including hematopoietic stem and progenitor cells, and is crucial for the proliferation and survival of hematopoietic cells. To further characterize the function of GATA-2, we examined the cellular turnover mechanism of GATA-2. In P815 cells, the half-life of endogenous GATA-2 was found to be as short as 30 min after cycloheximide treatment. This...

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Identifiers

PMID: 15966900
DOI: 10.1111/j.1365-2443.2005.00864.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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