Article
Characterization of cAMP-dependent proteolysis of GATA-6.
Biochemical and biophysical research communications - 15 Jul 2005
Ishida Akiko, Iijima Ryoko, Kobayashi Ayako, Maeda Masatomo
Abstract excerpt
Cyclic AMP-dependent proteolysis of GATA-6(Delta50) was characterized using inhibitors for intracellular signaling pathways. Among these kinase inhibitors, only H-89 and K252a inhibited the proteolysis induced by dbcAMP, a membrane permeable cAMP analogue, others such as PD98059, SB203580, calphostine C, PP1, and KN-93 did not do so. These results suggest that A-kinase, but not C-kinase, MEK, P38 MAP-kinases or...
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