Article
Regulation of GATA-binding protein 2 levels via ubiquitin-dependent degradation by Fbw7: involvement of cyclin B-cyclin-dependent kinase 1-mediated phosphorylation of THR176 in GATA-binding protein 2.
The Journal of biological chemistry - 17 Apr 2015
Nakajima Tomomi, Kitagawa Kyoko, Ohhata Tatsuya, Sakai Satoshi, Uchida Chiharu, Shibata Kiyoshi, Minegishi Naoko, Yumimoto Kanae, Nakayama Keiichi I, Masumoto Kazuma, Katou Fuminori, Niida Hiroyuki, Kitagawa Masatoshi
Abstract excerpt
A GATA family transcription factor, GATA-binding protein 2 (GATA2), participates in cell growth and differentiation of various cells, such as hematopoietic stem cells. Although its expression level is controlled by transcriptional induction and proteolytic degradation, the responsible E3 ligase has not been identified. Here, we demonstrate that F-box/WD repeat-containing protein 7 (Fbw7/Fbxw7), a component of...
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