Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CDK2 destabilizes tumor suppressor C/EBPα expression through ubiquitin-mediated proteasome degradation in acute myeloid leukemia.

Journal of cellular biochemistry - 1 Apr 2020

Thacker Gatha, Mishra Mukul, Sharma Akshay, Singh Anil Kumar, Sanyal Sabyasachi, Trivedi Arun Kumar

Abstract excerpt

Deregulation and functional inhibition of CCAAT-enhancer-binding protein α (C/EBPα), a key transcription factor of myeloid lineage leads to development of myeloid leukemia. In this study, we show that cyclin-dependent kinase 2 (CDK2) negatively regulates C/EBPα protein levels in myeloid leukemia cells. The overexpression of CDK2 inhibited C/EBPα both in a heterologous HEK293T and U937 myeloid leukemia cells. On...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CCAAT-Enhancer-Binding Protein-alpha
Share to Cyclin-Dependent Kinase 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

Share to K562 Cells

Share to Proteasome Endopeptidase Complex

Share to THP-1 Cells

Share to U937 Cells

Share to Ubiquitin

Source

Identifiers

PMID: 31692040
DOI: 10.1002/jcb.29516

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CDK2 destabilizes tumor suppressor C/EBPα expression through ubiquitin-mediated proteasome degradation in acute myeloid leukemia.PMID 31692040Read ↗

SKP2 Oncogene Is a Direct MYC Target Gene and MYC Down-regulates p27KIP1 through SKP2 in Human Leukemia CellsSemantic proximity Read ↗

Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemiaSemantic proximity Read ↗

Regulation of the C/EBPα signaling pathway in acute myeloid leukemia (Review)Semantic proximity Read ↗

Regulation of Ikaros function by casein kinase 2 and protein phosphatase 1Semantic proximity Read ↗

Targeting CDK1 promotes FLT3-activated acute myeloid leukemia differentiation through C/EBPα.Semantic proximity Read ↗

Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemiaSemantic proximity Read ↗

CK2 mediates phosphorylation and ubiquitin-mediated degradation of the PML tumor suppressor.Semantic proximity Read ↗

Mechanistic Basis for In Vivo Therapeutic Efficacy of CK2 Inhibitor CX-4945 in Acute Myeloid LeukemiaSemantic proximity Read ↗

CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional activation.Semantic proximity Read ↗

Cdk2-Null Mice Are Resistant to ErbB-2-Induced Mammary TumorigenesisSemantic proximity Read ↗

Rapid turnover of GATA-2 via ubiquitin-proteasome protein degradation pathway.Semantic proximity Read ↗

Disruption of the C/EBPα—miR-182 balance impairs granulocytic differentiationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.