Article
Characterization of DeltaN-Zfp36l2 mutant associated with arrest of early embryonic development and female infertility.
The Journal of biological chemistry - 13 Apr 2012
Ramos Silvia B V
Abstract excerpt
The zinc finger protein 36-like 2, Zfp36l2, has been implicated in female mouse infertility, because an amino-terminal truncation mutation (ΔN-Zfp36l2) leads to two-cell stage arrest of embryos derived from the homozygous mutant female gamete. Zfp36l2 is a member of the tristetraprolin (TTP) family of CCCH tandem zinc finger proteins that can bind to transcripts containing AU-rich elements (ARE), resulting in...
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