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Article

Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice.

Nature genetics - 1 Jul 2005

Wang Yuxun, Putnam Christopher D, Kane Michael F, Zhang Weijia, Edelmann Lisa, Russell Robert, Carrión Danaise V, Chin Lynda, Kucherlapati Raju, Kolodner Richard D, Edelmann Winfried

Abstract excerpt

Most cancers have multiple chromosomal rearrangements; the molecular mechanisms that generate them remain largely unknown. Mice carrying a heterozygous missense change in one of the DNA-binding domains of Rpa1 develop lymphoid tumors, and their homozygous littermates succumb to early embryonic le...

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Identifiers

PMID: 15965476
DOI: 10.1038/ng1587

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15965476-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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