Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RPL22L1 induction in colorectal cancer is associated with poor prognosis and 5-FU resistance

3 Oct 2019

Abstract excerpt

We have previously demonstrated that loss of the tumor suppressive activity of ribosomal protein (RP) RPL22 predisposes to development of leukemia in mouse models and aggressive disease in human patients; however, the role of RPL22 in solid tumors, specifically colorectal cancer (CRC), had not been explored. We report here that RPL22 is either deleted or mutated in 36% of CRC and provide new insights into its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal Cancer Treatments and Studies
Share to Genetic factors in colorectal cancer
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31581233
DOI: 10.1371/journal.pone.0222392

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RPL22L1 induction in colorectal cancer is associated with poor prognosis and 5-FU resistancePMID 31581233Read ↗

Knockdown of ribosomal protein L22-like 1 arrests the cell cycle and promotes apoptosis in colorectal cancerSemantic proximity Read ↗

Cancer-mutated ribosome protein L22 (RPL22/eL22) suppresses cancer cell survival by blocking p53-MDM2 circuitSemantic proximity Read ↗

RPL27 contributes to colorectal cancer proliferation and stemness via PLK1 signalingSemantic proximity Read ↗

Long non-coding RNA RAMS11 promotes metastatic colorectal cancer progressionSemantic proximity Read ↗

Disruption of the RP-MDM2-p53 pathway accelerates APC loss-induced colorectal tumorigenesis.Semantic proximity Read ↗

Cancer-associated mutations in the ribosomal protein L5 gene dysregulate the HDM2/p53-mediated ribosome biogenesis checkpoint.Semantic proximity Read ↗

Ribosomal protein RPL5 regulates colon cancer cell proliferation and migration through MAPK/ERK signaling pathwaySemantic proximity Read ↗

Loss of RPS27a expression regulates the cell cycle, apoptosis, and proliferation via the RPL11-MDM2-p53 pathway in lung adenocarcinoma cellsSemantic proximity Read ↗

PICT1 regulates TP53 via RPL11 and is involved in gastric cancer progressionSemantic proximity Read ↗

Involvement of ribosomal protein L11 expression in sensitivity of gastric cancer against 5‑FUSemantic proximity Read ↗

Deletion of ribosomal protein genes is a common vulnerability in human cancer, especially in concert with TP53 mutations.Semantic proximity Read ↗

Ribosomal Protein S27-Like in Colorectal Cancer: A Candidate for Predicting PrognosesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.