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Article

Many ribosomal protein genes are cancer genes in zebrafish.

PLoS biology - 1 May 2004

Amsterdam Adam, Sadler Kirsten C, Lai Kevin, Farrington Sarah, Bronson Roderick T, Lees Jacqueline A, Hopkins Nancy

Abstract excerpt

We have generated several hundred lines of zebrafish (Danio rerio), each heterozygous for a recessive embryonic lethal mutation. Since many tumor suppressor genes are recessive lethals, we screened our colony for lines that display early mortality and/or gross evidence of tumors. We identified 12 lines with elevated cancer incidence. Fish from these lines develop malignant peripheral nerve sheath tumors, and in...

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Identifiers

PMID: 15138505
DOI: 10.1371/journal.pbio.0020139
PMCID: PMC406397

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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